TY - JOUR
T1 - Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle
AU - Nakatake, Yuhki
AU - Hoshikawa, Masamitsu
AU - Asaki, Toshiyuki
AU - Kassai, Yoshiaki
AU - Itoh, Nobuyuki
N1 - Funding Information:
This work was supported in part by the Yamada Science Foundation, the Yamanouchi Foundation on Metabolic Disorders, a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan, and the Human Frontier Science Program, France.
PY - 2001/2/16
Y1 - 2001/2/16
N2 - We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (∼46% and ∼40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the inner root sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.
AB - We isolated cDNA encoding a novel fibroblast growth factor (FGF-22) (170 amino acids) from human placenta. Of the FGF family members, FGF-22, which appears to be a secreted protein, is most similar to FGF-10 and FGF-7 (∼46% and ∼40% amino acid identities, respectively). The human FGF-22 gene was localized on chromosome 19p13.3. We also isolated mouse cDNA encoding FGF-22 (162 amino acids) from the skin. Mouse FGF-22 shows high homology (87% amino acid identity) to human FGF-22. Mouse FGF-22 mRNA was found to be preferentially expressed in the skin among the mouse adult tissues examined by Northern blotting analysis. By in situ hybridization, FGF-22 mRNA in the skin was found to be preferentially expressed in the inner root sheath of the hair follicle. Therefore, FGF-22 is expected to be a unique FGF that plays a role in hair development.
KW - Fibroblast growth factor
KW - Gene expression
KW - Gene family
KW - Growth factor
KW - Hair
KW - Skin
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U2 - 10.1016/S0167-4781(00)00302-X
DO - 10.1016/S0167-4781(00)00302-X
M3 - Article
C2 - 11342227
AN - SCOPUS:0035895835
SN - 0167-4781
VL - 1517
SP - 460
EP - 463
JO - Biochimica et Biophysica Acta - Gene Structure and Expression
JF - Biochimica et Biophysica Acta - Gene Structure and Expression
IS - 3
ER -