Identification of the toxic trigger in mushroom poisoning

Masanori Matsuura; Yoko Saikawa; Kosei Inui; Koichi Nakae; Masayuki Igarashi; Kimiko Hashimoto; Masaya Nakata

doi:10.1038/nchembio.179

Identification of the toxic trigger in mushroom poisoning

Masanori Matsuura, Yoko Saikawa, Kosei Inui, Koichi Nakae, Masayuki Igarashi, Kimiko Hashimoto, Masaya Nakata

応用化学科

研究成果: Article › 査読

61 被引用数 (Scopus)

抄録

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.

本文言語	English
ページ（範囲）	465-467
ページ数	3
ジャーナル	Nature Chemical Biology
巻	5
号	7
DOI	https://doi.org/10.1038/nchembio.179
出版ステータス	Published - 2009 7月

ASJC Scopus subject areas

分子生物学
細胞生物学

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10.1038/nchembio.179

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AU - Hashimoto, Kimiko

AU - Nakata, Masaya

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Identification of the toxic trigger in mushroom poisoning

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