TY - JOUR
T1 - Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium
AU - Iwasaki, Keitaro
AU - Iwasaki, Arihiro
AU - Sumimoto, Shimpei
AU - Matsubara, Teruhiko
AU - Sato, Toshinori
AU - Nozaki, Tomoyoshi
AU - Saito-Nakano, Yumiko
AU - Suenaga, Kiyotake
N1 - Funding Information:
This work was supported by JSPS KAKENHI (Grant Numbers 18K14346 and 16H03285) and Keio Gijuku Academic Development Funds. We thank Y. Umeki for technical assistance and the Japanese Red Cross Society for providing human RBCs and plasma. The P. falciparum 3D7 line was obtained from MR4 (contributed by D. J. Carucci, MRA-102). We thank professor H. El-Seedi (Uppsala University) for helpful discussions.
Funding Information:
This work was supported by JSPS KAKENHI (Grant Numbers 18K14346 and 16H03285) and Keio Gijuku Academic Development Funds. We thank Y. Umeki for technical assistance and the Japanese Red Cross Society for providing human RBCs and plasma. The P. falciparum 3D7 line was obtained from MR4 (contributed by D. J. Carucci, MRA-102). We thank professor H. El-Seedi (Uppsala University) for helpful discussions.
Publisher Copyright:
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy.
PY - 2020/2/28
Y1 - 2020/2/28
N2 - An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.
AB - An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.
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U2 - 10.1021/acs.jnatprod.9b01147
DO - 10.1021/acs.jnatprod.9b01147
M3 - Article
C2 - 32040324
AN - SCOPUS:85079788127
SN - 0163-3864
VL - 83
SP - 481
EP - 488
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -
