@article{cb32e0c414ea4e28a22d60427234f170,
title = "IL-6 and related cytokines as the critical lynchpins between inflammation and cancer",
abstract = "Inflammatory responses play pivotal roles in cancer development, including tumor initiation, promotion, progression, and metastasis. Cytokines are now recognized as important mediators linking inflammation and cancer, and are therefore potential therapeutic and preventive targets as well as prognostic factors. The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis. This review discusses molecular mechanisms linking the IL-6 cytokine family to solid malignancies and their treatment.",
keywords = "Colorectal cancer, Gastric cancer, Gp130, Hepatocellular carcinoma, IL-11, IL-6, STAT3",
author = "Koji Taniguchi and Michael Karin",
note = "Funding Information: We thank Dr. Sergei Grivennikov (Fox Chase Cancer Center) for his comments. This work was supported by the Postdoctoral Fellowship for Research Abroad , the Research Fellowship for Young Scientists and the Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation from the Japan Society for the Promotion of Science , the Uehara Memorial Foundation Fellowship , the Mochida Memorial Foundation for Medical and Pharmaceutical Research , and the Kanae Foundation for the Promotion of Medical Science to K.T.; and by the National Institutes of Health and the American Association for Cancer Research to M.K., who is an American Cancer Society Research Professor and holds the Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases.",
year = "2014",
month = feb,
doi = "10.1016/j.smim.2014.01.001",
language = "English",
volume = "26",
pages = "54--74",
journal = "Seminars in Immunology",
issn = "1044-5323",
publisher = "Academic Press Inc.",
number = "1",
}
