TY - JOUR
T1 - Immune-mediated neuropathy with anti-disialosyl IgM antibodies in diffuse large B-cell lymphoma
T2 - A case report and literature review
AU - Shihashi, Gen
AU - Yagi, Takuya
AU - Suzuki, Shigeaki
AU - Seki, Morinobu
AU - Kohashi, Sumiko
AU - Ueda, Tomoki
AU - Kameyama, Kaori
AU - Kusunoki, Susumu
AU - Nakajima, Hideaki
AU - Okamoto, Shinichiro
AU - Suzuki, Norihiro
N1 - Publisher Copyright:
© 2015 The Japanese Society of Internal Medicine.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). He was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and received high-dose intravenous immunoglobulin for the treatment of neuropathy. After initiating the treatments, the patient's neurological impairment improved dramatically. He currently remains in complete remission without a flare-up of the polyneuropathy. Based upon our experience and other case reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we conclude that determining the anti-ganglioside antibody profile and beginning early treatment should be considered promptly for patients with malignant lymphoma who develop polyneuropathy.
AB - A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). He was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and received high-dose intravenous immunoglobulin for the treatment of neuropathy. After initiating the treatments, the patient's neurological impairment improved dramatically. He currently remains in complete remission without a flare-up of the polyneuropathy. Based upon our experience and other case reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we conclude that determining the anti-ganglioside antibody profile and beginning early treatment should be considered promptly for patients with malignant lymphoma who develop polyneuropathy.
KW - Anti-ganglioside antibody
KW - Diffuse large B-cell lymphoma
KW - Guillain-Barré syndrome
KW - Immune-mediated neuropathy
KW - Malignant lymphoma
KW - Paraneoplastic syndrome
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U2 - 10.2169/internalmedicine.54.4451
DO - 10.2169/internalmedicine.54.4451
M3 - Review article
C2 - 26134199
AN - SCOPUS:84936131129
SN - 0918-2918
VL - 54
SP - 1647
EP - 1651
JO - Internal Medicine
JF - Internal Medicine
IS - 13
ER -