Immunohistological analysis of tumour growth factor β1 expression in normal and inflamed salivary glands

Y. Kizu, H. Sakurai, S. Katagiri, N. Shinozaki, M. Ono, K. Tsubota, I. Saito

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Aim. To determine whether transforming growth factor-β1 (TGF-β1) has a pathogenetic role in disease of the salivary glands. Methods. An indirect immunohistochemical technique was used to analyse TGF-β1 expression in six specimens of normal salivary gland and 23 surgical specimens. Results. TGF-β1 was strongly expressed in the ductal epithelial cells of normal salivary gland tissues (six of six cases) and in inflammatory conditions (eight of 11 cases). In contrast, TGF-β1 was not detectable in ductal epithelial cells expressing HLA-DR around infiltrating CD4+ CD45RO+ activated T cells, in the salivary gland tissue of patients with Sjogren's syndrome, Conclusion. Because TGF-β1 has an essential role in the mucosal immunity of salivary glands, abnormal expression of this cytokine must be regarded as a candidate in the pathogenesis of Sjogren's syndrome.

本文言語English
ページ(範囲)728-732
ページ数5
ジャーナルJournal of Clinical Pathology
49
9
DOI
出版ステータスPublished - 1996
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学

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