In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment

Takashi Ota; Masamitsu Nakayama; Yoshihiko Kanno; Tetsuya Suzuki; Norihisa Miki

doi:10.1109/MEMSYS.2018.8346575

In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment

Takashi Ota, Masamitsu Nakayama, Yoshihiko Kanno, Tetsuya Suzuki, Norihisa Miki

機械工学科

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

In this report, we experimentally investigated the blood hemofiltration capacity of a nanoporous dialysis membrane (poly(ether sulfone), PES) whose surface was modified with fluorine-doped diamond-like carbon(f-DLC). Surface modification of the nanoporous membrane without clogging the nanopores is challenging. In vitro experiments revealed that the modified membrane successfully exhibited water permeability of one-tenth of the untreated. In vivo experiments with ultra-small hemofiltration devices composed of f-DLC PES membranes using SD rats were also conducted for the first time. The results proved that the f-DLC coated PES membrane can be used for hemofiltration, which will extend the lifetime of microfluidics-based implantable artificial kidney.

本文言語	English
ホスト出版物のタイトル	2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
出版社	Institute of Electrical and Electronics Engineers Inc.
ページ	412-414
ページ数	3
ISBN（電子版）	9781538647820
DOI	https://doi.org/10.1109/MEMSYS.2018.8346575
出版ステータス	Published - 2018 4月 24
イベント	31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast, United Kingdom 継続期間: 2018 1月 21 → 2018 1月 25

出版物シリーズ

名前	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
巻	2018-January
ISSN（印刷版）	1084-6999

Other

Other	31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
国/地域	United Kingdom
City	Belfast
Period	18/1/21 → 18/1/25

ASJC Scopus subject areas

電子材料、光学材料、および磁性材料
凝縮系物理学
機械工学
電子工学および電気工学

文献へのアクセス

10.1109/MEMSYS.2018.8346575

他のファイルとリンク

フィンガープリント

「In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Ota, T., Nakayama, M., Kanno, Y., Suzuki, T., & Miki, N. (2018). In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (pp. 412-414). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2018.8346575

In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. / Ota, Takashi; Nakayama, Masamitsu; Kanno, Yoshihiko その他.
2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc., 2018. p. 412-414 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January).

研究成果: Conference contribution

Ota, T, Nakayama, M, Kanno, Y, Suzuki, T & Miki, N 2018, In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. in 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 412-414, 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 18/1/21. https://doi.org/10.1109/MEMSYS.2018.8346575

Ota T, Nakayama M, Kanno Y, Suzuki T , Miki N. In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc. 2018. p. 412-414. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2018.8346575

Ota, Takashi ; Nakayama, Masamitsu ; Kanno, Yoshihiko その他. / In vitro and in vivo tests of nanoporous membrane coated with biocompatible fluorine-doped diamond-like carbon for hemofiltration treatment. 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 412-414 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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abstract = "In this report, we experimentally investigated the blood hemofiltration capacity of a nanoporous dialysis membrane (poly(ether sulfone), PES) whose surface was modified with fluorine-doped diamond-like carbon(f-DLC). Surface modification of the nanoporous membrane without clogging the nanopores is challenging. In vitro experiments revealed that the modified membrane successfully exhibited water permeability of one-tenth of the untreated. In vivo experiments with ultra-small hemofiltration devices composed of f-DLC PES membranes using SD rats were also conducted for the first time. The results proved that the f-DLC coated PES membrane can be used for hemofiltration, which will extend the lifetime of microfluidics-based implantable artificial kidney.",

author = "Takashi Ota and Masamitsu Nakayama and Yoshihiko Kanno and Tetsuya Suzuki and Norihisa Miki",

note = "Funding Information: This work was partly supported by JSPS KAKENHI Grant Number 15H03547. Publisher Copyright: {\textcopyright} 2018 IEEE.; 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 ; Conference date: 21-01-2018 Through 25-01-2018",

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