TY - JOUR
T1 - In vitro behavior of Porfimer sodium and Talaporfin sodium with high intensity pulsed irradiation
AU - Ohmori, Sayaka
AU - Arai, Tsunenori
N1 - Funding Information:
Acknowledgments The authors thank Meiji Seika Kaisha Ltd. for providing kindly the Talaporfin sodium. This work has been partially supported by a grant-in-aid from the 21st Century COE Program of the Ministry of Education, Culture, Sports, Science and Technology, Japan to Keio University.
PY - 2006/12
Y1 - 2006/12
N2 - We studied pulse energy density dependence of two distinctive clinical photosensitizers, Porfimer sodium and Talaporfin sodium, in terms of oxygen consumption, photodegradation in these photosensitizer solutions, and rat prostate cancer cell line photocytotoxicity. The transient transmittances during the pulsed irradiation to these photosensitizer solutions were measured with the pulse energy densities ranging from 0.31 to 31 mJ/cm2. We revealed that Talaporfin sodium was easier to produce absorption saturation than Porfimer sodium. The significant suppression of Talaporfin sodium mediated oxygen consumption, photodegradation, and photocytotoxicity which were observed with pulse energy densities increasing from 0.5 to 10 mJ/cm2. This result could be mainly attributed to absorption saturation. On the other hand, Porfimer sodium did not display significant absorption saturation with the pulse energy densities ranging from 0.31 to 31 mJ/cm2. The photodegradation mechanism for Porfimer sodium changed at high pulse energy density. This phenomenon might accelerate the photodegradation and cause the photocytotoxicity suppression.
AB - We studied pulse energy density dependence of two distinctive clinical photosensitizers, Porfimer sodium and Talaporfin sodium, in terms of oxygen consumption, photodegradation in these photosensitizer solutions, and rat prostate cancer cell line photocytotoxicity. The transient transmittances during the pulsed irradiation to these photosensitizer solutions were measured with the pulse energy densities ranging from 0.31 to 31 mJ/cm2. We revealed that Talaporfin sodium was easier to produce absorption saturation than Porfimer sodium. The significant suppression of Talaporfin sodium mediated oxygen consumption, photodegradation, and photocytotoxicity which were observed with pulse energy densities increasing from 0.5 to 10 mJ/cm2. This result could be mainly attributed to absorption saturation. On the other hand, Porfimer sodium did not display significant absorption saturation with the pulse energy densities ranging from 0.31 to 31 mJ/cm2. The photodegradation mechanism for Porfimer sodium changed at high pulse energy density. This phenomenon might accelerate the photodegradation and cause the photocytotoxicity suppression.
KW - Absorption saturation
KW - Photodynamic therapy
KW - Porfimer sodium
KW - Pulsed irradiation
KW - Talaporfin sodium
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U2 - 10.1007/s10103-006-0403-0
DO - 10.1007/s10103-006-0403-0
M3 - Article
C2 - 17024319
AN - SCOPUS:33845338735
SN - 0268-8921
VL - 21
SP - 213
EP - 223
JO - Lasers in Medical Science
JF - Lasers in Medical Science
IS - 4
ER -
