In vitro behavior of Porfimer sodium and Talaporfin sodium with high intensity pulsed irradiation

Sayaka Ohmori, Tsunenori Arai

研究成果: Article査読

8 被引用数 (Scopus)

抄録

We studied pulse energy density dependence of two distinctive clinical photosensitizers, Porfimer sodium and Talaporfin sodium, in terms of oxygen consumption, photodegradation in these photosensitizer solutions, and rat prostate cancer cell line photocytotoxicity. The transient transmittances during the pulsed irradiation to these photosensitizer solutions were measured with the pulse energy densities ranging from 0.31 to 31 mJ/cm2. We revealed that Talaporfin sodium was easier to produce absorption saturation than Porfimer sodium. The significant suppression of Talaporfin sodium mediated oxygen consumption, photodegradation, and photocytotoxicity which were observed with pulse energy densities increasing from 0.5 to 10 mJ/cm2. This result could be mainly attributed to absorption saturation. On the other hand, Porfimer sodium did not display significant absorption saturation with the pulse energy densities ranging from 0.31 to 31 mJ/cm2. The photodegradation mechanism for Porfimer sodium changed at high pulse energy density. This phenomenon might accelerate the photodegradation and cause the photocytotoxicity suppression.

本文言語English
ページ(範囲)213-223
ページ数11
ジャーナルLasers in Medical Science
21
4
DOI
出版ステータスPublished - 2006 12月
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 皮膚病学

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