Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics

S. Miura, E. Sekizuka, H. Nagata, C. Oshio, H. Minamitani, M. Suematsu, M. Suzuki, Y. Hamada, K. Kobayashi, H. Asakura, M. Tsuchiya

研究成果: Article査読

39 被引用数 (Scopus)


The effect of olive oil administration on lymphocyte transport through mesenteric lymphatics was examined to see the possible involvement of nutritional absorption in lymphocyte traffic from the intestinal mucosa. After the olive oil administration to rats, remarkable increase in lymphocyte flux was observed within 2 h in lymph samples collected from rats with lymphatic fistula. The use of a high-speed microscopic video system made it possible to analyze accurately the lymphocyte transport in rapid movement that could not be detected by any of the ordinary video systems. The direct observation of mesenteric collecting lymphatics by this system showed an increment of lymphocyte transport from the intestinal mucosa lipid absorption in 2 h. The contraction frequency of intestinal collecting lymphatics was also enhanced by olive oil administration. The densitometric analysis on video image was applied to estimate the extent of lipid absorption. The combination of a high-speed video system and the densitometric analysis revealed that the increase in lymphocyte flux occurred before lipid absorption reached its maximum and also demonstrated that the lymphocyte transport returned to control levels under the maximal absorptive condition. The results suggest that the fat absorption could be an important factor influencing the lymphocyte transport in the lymphatic system of intestine.

ジャーナルAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
出版ステータスPublished - 1987

ASJC Scopus subject areas

  • 生理学
  • 肝臓学
  • 消化器病学
  • 生理学(医学)


「Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。