TY - JOUR
T1 - Induced Regulatory T Cells
T2 - Their Development, Stability, and Applications
AU - Kanamori, Mitsuhiro
AU - Nakatsukasa, Hiroko
AU - Okada, Masahiro
AU - Lu, Qianjin
AU - Yoshimura, Akihiko
N1 - Funding Information:
This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant-in-Aid for Young Scientists (A) and (S) 25221305, Advanced Research and Development Programs for Medical Innovation (AMED-CREST), the Takeda Science Foundation, the Uehara Memorial Foundation, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, the Kanae Foundation, the SENSHIN Medical Research Foundation, and Keio Gijuku Academic Developmental Funds.
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from naïve T cells after stimulation in the presence of TGF-β and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.
AB - Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from naïve T cells after stimulation in the presence of TGF-β and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.
KW - Clostridium species
KW - DNA methylation
KW - TGF-β
KW - regulatory T cells
KW - transcription factors
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U2 - 10.1016/j.it.2016.08.012
DO - 10.1016/j.it.2016.08.012
M3 - Review article
C2 - 27623114
AN - SCOPUS:84992751908
SN - 1471-4906
VL - 37
SP - 803
EP - 811
JO - Trends in Immunology
JF - Trends in Immunology
IS - 11
ER -