TY - JOUR
T1 - Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
AU - Hayashida, Kentaro
AU - Sano, Motoaki
AU - Ohsawa, Ikuroh
AU - Shinmura, Ken
AU - Tamaki, Kayoko
AU - Kimura, Kensuke
AU - Endo, Jin
AU - Katayama, Takaharu
AU - Kawamura, Akio
AU - Kohsaka, Shun
AU - Makino, Shinji
AU - Ohta, Shigeo
AU - Ogawa, Satoshi
AU - Fukuda, Keiichi
N1 - Funding Information:
We thank M. Okada (NIHON KODEN), S. Kotouda (LMS laboratory and Medical Supplies), C. Ogawa, K. Nishimaki, M. Kamimura, M, Abe, Y. Miyake, H. Kawaguchi, H. Shiozawa, and M. Ono for their technical assistance. M. Sano is a core member of the Global Center-of-Excellence (GCOE) for Human Metabolomics Systems Biology from MEXT. This work was supported by a PRESTO (Metabolism and Cellular Function) grant from the Japanese Science and Technology Agency awarded to M. Sano.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/8/15
Y1 - 2008/8/15
N2 - Inhalation of hydrogen (H2) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, we investigate whether H2 gas confers cardioprotection against ischemia-reperfusion injury in rats. In isolated perfused hearts, H2 gas enhances the recovery of left ventricular function following anoxia-reoxygenation. Inhaled H2 gas is rapidly transported and can reach 'at risk' ischemic myocardium before coronary blood flow of the occluded infarct-related artery is reestablished. Inhalation of H2 gas at incombustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H2 gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery.
AB - Inhalation of hydrogen (H2) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, we investigate whether H2 gas confers cardioprotection against ischemia-reperfusion injury in rats. In isolated perfused hearts, H2 gas enhances the recovery of left ventricular function following anoxia-reoxygenation. Inhaled H2 gas is rapidly transported and can reach 'at risk' ischemic myocardium before coronary blood flow of the occluded infarct-related artery is reestablished. Inhalation of H2 gas at incombustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H2 gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery.
KW - Anti-oxidant
KW - H
KW - Ischemia-reperfusion injury
KW - Myocardial infarction
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U2 - 10.1016/j.bbrc.2008.05.165
DO - 10.1016/j.bbrc.2008.05.165
M3 - Article
C2 - 18541148
AN - SCOPUS:45949085302
SN - 0006-291X
VL - 373
SP - 30
EP - 35
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -