TY - JOUR
T1 - Inhibition of mouse epidermal 12‐lipoxygenase by 2,3,4‐trimethyl‐6‐(12‐hydroxy‐5,10‐dodecadiynyl)‐l,4‐benzoquinone (AA861)
AU - Nakadate, Teruo
AU - Yamamoto, Satoshi
AU - Aizu, Eriko
AU - Kato, Ryuichi
PY - 1985/1
Y1 - 1985/1
N2 - 2,3,5‐Trimethyl‐6‐(12‐hydroxy‐5, 10‐dodecadiynyl)‐1.4‐benzoquinone (AA861) strongly inhibited epidermal lipoxygenase activity which was determined by the formation of [14 C]12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid by incubating [l4 C]arachidonic acid with cytosol fraction of epidermal homogenate of ***CD‐1 mice. AA861 failed to inhibit epidermal cyclooxygenase activity. The present results indicate that AA861 is a potent inhibitor of 12‐lipoxygenase in mouse epidermis (IC50 1.9 μM). 1985 Royal Pharmaceutical Society of Great Britain
AB - 2,3,5‐Trimethyl‐6‐(12‐hydroxy‐5, 10‐dodecadiynyl)‐1.4‐benzoquinone (AA861) strongly inhibited epidermal lipoxygenase activity which was determined by the formation of [14 C]12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid by incubating [l4 C]arachidonic acid with cytosol fraction of epidermal homogenate of ***CD‐1 mice. AA861 failed to inhibit epidermal cyclooxygenase activity. The present results indicate that AA861 is a potent inhibitor of 12‐lipoxygenase in mouse epidermis (IC50 1.9 μM). 1985 Royal Pharmaceutical Society of Great Britain
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U2 - 10.1111/j.2042-7158.1985.tb04938.x
DO - 10.1111/j.2042-7158.1985.tb04938.x
M3 - Article
C2 - 2858536
AN - SCOPUS:0022005227
SN - 0022-3573
VL - 37
SP - 71
EP - 73
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 1
ER -