Inhibition of Phosphatidylinositol-specific Phospholipase C Activity by Fluvirucin B2

Hideaki Ui; Masaya Imoto; Kazuo Umezawa

doi:10.7164/antibiotics.48.387

Inhibition of Phosphatidylinositol-specific Phospholipase C Activity by Fluvirucin B₂

Hideaki Ui, Masaya Imoto, Kazuo Umezawa

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研究成果: Article › 査読

17 被引用数 (Scopus)

抄録

We isolated fluvirucin B₂from the culture broth of Streptomyces as an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). It inhibited PI-PLC of A431 cell cytosol with an IC₅₀ of 1.6μg/ml. Fluvirucin B₂also inhibited PI-PLC in cultured A431 cells, whereas it did not inhibit phosphatidylinositol synthesis and macromolecular synthesis markedly. It also inhibited epidermal growth factor-induced rapid rounding of A431 cells, in which PI turnover is involved.

本文言語	English
ページ（範囲）	387-390
ページ数	4
ジャーナル	The Journal of Antibiotics
巻	48
号	5
DOI	https://doi.org/10.7164/antibiotics.48.387
出版ステータス	Published - 1995 1月 1

ASJC Scopus subject areas

薬理学
創薬

文献へのアクセス

10.7164/antibiotics.48.387

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引用スタイル

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