@article{a3144d09f7984e0daaa5c1b70455aa93,
title = "Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats",
abstract = "The effects of intracerebroventricular injection of atrial natriuretic polypeptide (ANP) and angiotensin II (AII) on the concentration of dopamine, noradrenaline, serotonin and their primary metabolites in the rat brain were studied using high performance liquid chromatography with electrochemical detection. ANP (2 and 5 μg) decreased the level of dopamine and its metabolite in the septum and hypothalamus. In contrast, AII (100 ng) increased their levels in these brain regions. The simultaneous administration of ANP (5 μg) with AII (100 ng) resulted in a marked reduction of the AII-induced increase of dopamine and its metabolite. No significant changes were observed in the concentrations of noradrenaline and serotonin throughout the brain. These results suggest that the central action of ANP is mediated in part via the dopaminergic system.",
keywords = "Angiotensin II, Atrial natriuretic polypeptide, Dopamine, Hypothalamus, Noradrenaline, Septum, Serotonin",
author = "Nakao Kazuwa and Katsuura Goro and Morii Narito and Itoh Hiroshi and Shiono Shozo and Sugawara Akira and Sakamoto Makoto and Saito Yoshihiko and Eigyo Masami and Yamada Takayuki and Sutsushita Akira and Hiroo Imura",
note = "Funding Information: orders, by a research grant for cardiovascular diseases (60A-3) from the Japanese Ministry of Health and Welfare and by the Japan Heart Foundation Research Grant for 1985. Funding Information: We thank Mrs. H. Tabata, Miss K. Horii, Miss Y. Uchida and Miss A. Furu for secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture, the Japanese Ministry of Health and Welfare 'Disorders of Adrenal Hormone' Research Committee, Japan, 1985, Japan Tobacco Inc. and the Yamanouchi Foundation for Research on Metabolic Dis-",
year = "1986",
month = nov,
day = "19",
doi = "10.1016/0014-2999(86)90570-4",
language = "English",
volume = "131",
pages = "171--177",
journal = "European journal of pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2-3",
}