Inhibitory effect of lidocaine on colonic spasm during colonoscopy: A multicenter double-blind, randomized controlled trial

Daiki Nemoto, Sho Suzuki, Hideki Mori, Shinichi Katsuki, Tomoyuki Iwaki, Masato Aizawa, Yoji Takeuchi, Toshio Uraoka, Tomoki Matsuda, Tomoki Fujita, David G. Hewett, Kazutomo Togashi

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Objectives: Colonic spasm can interfere with colonoscopy, but antispasmodic agents can cause complications. This study aimed to assess the inhibitory effect of topical lidocaine compared with a placebo control. Methods: In five tertiary-care hospitals in Japan, 128 patients requiring endoscopic resection of a colorectal lesion were enrolled and randomly and double-blindly allocated to colonoscopy with topical administration of 2% lidocaine solution 20mL (LID, n = 64) or normal saline 20mL (control, n = 64). During colonoscopy, the assigned solution was applied with a spray catheter near the lesion and the area was observed for three minutes. primary endpoint was the inhibitory effect at three time-points (1, 2 and 3 minutes after dispersion), using a three-point scale (excellent, fair, poor). Secondary endpoints were rebound spasm and adverse events. All endpoints were scored in real time. Serum lidocaine levels were measured in 32 patients (LID 16, control 16). Results: There were no significant differences between groups in patient demographics. At all time-points, the proportion of patients with “excellent” scores was greater in LID group than control group, with significant differences observed at 2 minutes (p = 0.02) and 3 minutes (p = 0.02). In LID group, the rate of “excellent” scores increased by 12.5% at 2 minutes and was maintained at 3 minutes. Rebound spasm did not occur in LID group, compared with 15.6% of control group (p = 0.001). There were no adverse events in LID group. All serum lidocaine levels were below detectable levels. Conclusions: Topical lidocaine is an effective and safe method for suppressing colorectal spasm during colonoscopy (UMIN000024733).

本文言語English
ページ(範囲)173-179
ページ数7
ジャーナルDigestive Endoscopy
31
2
DOI
出版ステータスPublished - 2019 3月
外部発表はい

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング
  • 消化器病学

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