Interleukin-18 and Crohn's disease

Takanori Kanai, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Toshifumi Hibi

研究成果: Article査読

28 被引用数 (Scopus)

抄録

The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.

本文言語English
ページ(範囲)37-42
ページ数6
ジャーナルDigestion
63
SUPPL. 1
DOI
出版ステータスPublished - 2001

ASJC Scopus subject areas

  • 消化器病学

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