Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

Hoon Ki Sung; Tohru Morisada; Chung Hyun Cho; Yuichi Oike; Jayhun Lee; Eon Ki Sung; Jae Hoon Chung; Toshio Suda; Gou Young Koh

doi:10.1016/j.bbrc.2006.04.121

Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

Hoon Ki Sung, Tohru Morisada, Chung Hyun Cho, Yuichi Oike, Jayhun Lee, Eon Ki Sung, Jae Hoon Chung, Toshio Suda, Gou Young Koh

研究成果: Article › 査読

16 被引用数 (Scopus)

抄録

Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

本文言語	English
ページ（範囲）	545-551
ページ数	7
ジャーナル	Biochemical and Biophysical Research Communications
巻	345
号	2
DOI	https://doi.org/10.1016/j.bbrc.2006.04.121
出版ステータス	Published - 2006 6月 30
外部発表	はい

ASJC Scopus subject areas

生物理学
生化学
分子生物学
細胞生物学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1016/j.bbrc.2006.04.121

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引用スタイル

@article{b9827ece34b54df28203bdcf074780a1,

title = "Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis",

abstract = "Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.",

keywords = "Endothelial cells, Lymphatics, Radiation therapy, Tumor",

author = "Sung, {Hoon Ki} and Tohru Morisada and Cho, {Chung Hyun} and Yuichi Oike and Jayhun Lee and Sung, {Eon Ki} and Chung, {Jae Hoon} and Toshio Suda and Koh, {Gou Young}",

note = "Funding Information: We thank the members of Laboratory of Cell Biology in KRIBB for help in performing the irradiation of the mice, and Jennifer Macke for help in preparing the manuscript. Supported by a Grant of the KOSEF (F01-2004-000-10233-0) and National Research Laboratory Program (2004-02376), Ministry of Science and Technology, Republic of Korea.",

year = "2006",

month = jun,

day = "30",

doi = "10.1016/j.bbrc.2006.04.121",

language = "English",

volume = "345",

pages = "545--551",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

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TY - JOUR

T1 - Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

AU - Sung, Hoon Ki

AU - Morisada, Tohru

AU - Cho, Chung Hyun

AU - Oike, Yuichi

AU - Lee, Jayhun

AU - Sung, Eon Ki

AU - Chung, Jae Hoon

AU - Suda, Toshio

AU - Koh, Gou Young

N1 - Funding Information: We thank the members of Laboratory of Cell Biology in KRIBB for help in performing the irradiation of the mice, and Jennifer Macke for help in preparing the manuscript. Supported by a Grant of the KOSEF (F01-2004-000-10233-0) and National Research Laboratory Program (2004-02376), Ministry of Science and Technology, Republic of Korea.

PY - 2006/6/30

Y1 - 2006/6/30

N2 - Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

AB - Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

KW - Endothelial cells

KW - Lymphatics

KW - Radiation therapy

KW - Tumor

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U2 - 10.1016/j.bbrc.2006.04.121

DO - 10.1016/j.bbrc.2006.04.121

M3 - Article

C2 - 16690025

AN - SCOPUS:33646844096

SN - 0006-291X

VL - 345

SP - 545

EP - 551

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

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ASJC Scopus subject areas

UN SDG

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