@article{bbc4c849f98848a8b780c638c0e3c960,
title = "Inverse Association between Height-Increasing Alleles and Extreme Longevity in Japanese Women",
abstract = "Growth hormone (GH)/insulin-like growth factor-1 (IGF-1)/insulin signaling is one of the most plausible biological pathways regulating aging and longevity. Previous studies have demonstrated that several single nucleotide polymorphisms (SNPs) in the GH/IGF-1/insulin signaling-associated genes influence both longevity and adult height, suggesting the possibility of a shared genetic architecture between longevity and height. We therefore examined the relationship between 30 height-associated SNPs and extreme longevity in a Japanese population consisting of 428 centenarians and 4,026 younger controls. We confirmed that height-increasing genetic scores (HGSs) constructed based on 30 SNPs were significantly associated with height in the controls (p = 6.951023). HGS was significantly and inversely associated with extreme longevity in women (p = .011), but not in men, although no SNPs were significantly associated with extreme longevity after Bonferroni correction. The odds ratio for extreme longevity in the lowest HGS group (=27) and the second lowest HGS group (2830) relative to the highest HGS group (=37) was 1.71 (p = .056) and 1.69 (p = .034), respectively, for women. In conclusion, the present study demonstrated an inverse association between height-increasing alleles with extreme longevity in Japanese women, providing novel insight into the genetic architecture of longevity and aging.",
keywords = "Centenarian, Human genetics, IGF-1, Longevity",
author = "Kumpei Tanisawa and Nobuyoshi Hirose and Yasumichi Arai and Hiroshi Shimokata and Yoshiji Yamada and Hisashi Kawai and Motonaga Kojima and Shuichi Obuchi and Hirohiko Hirano and Hiroyuki Suzuki and Yoshinori Fujiwara and Yu Taniguchi and Shoji Shinkai and Kazushige Ihara and Maki Sugaya and Mitsuru Higuchi and Tomio Arai and Seijiro Mori and Motoji Sawabe and Noriko Sato and Masaaki Muramatsu and Masashi Tanaka",
note = "Funding Information: This work was supported by grants-in-aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; by GMEXT/JSPS KAKENHI Grants (JP Numbers: A-16H01872, A-25242062, A-22240072, B-21390459, C-26670481, C-21590411, and CER-24650414 to M.T.); by Grants-in-Aid for Research on Intractable Diseases (Mitochondrial Disorders; grant numbers 23-016, 23–116, and 24-005 (to M.T.) from the Ministry of Health, Labor, and Welfare of Japan; by the Practical Research Project for Rare / Intractable Diseases from the Japan Agency for Medical Research and Development, AMED (15ek0109088h0001 and 15ek0109088s0401 to M.T.); by the Takeda Science Foundation (to M.T.); by the Smoking Research Foundation (to T.A. and M.S.); and by the Joint Usage/Research Program of the Medical Research Institute, Tokyo Medical and Dental University (to M.M.). Publisher Copyright: {\textcopyright} 2018 Oxford University Press. All rights reserved.",
year = "2018",
month = apr,
day = "17",
doi = "10.1093/gerona/glx155",
language = "English",
volume = "73",
pages = "588--595",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "5",
}