Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism

Yoichiro Ijima; Kaori Matoishi; Yosuke Terao; Nobuhide Doi; Hiroshi Yanagawa; Hiromichi Ohta

doi:10.1039/b416398b

Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism

Yoichiro Ijima, Kaori Matoishi, Yosuke Terao, Nobuhide Doi, Hiroshi Yanagawa, Hiromichi Ohta

生命情報学科

研究成果: Article › 査読

56 被引用数 (Scopus)

抄録

The introduction of two mutations (G74C/C188S) based on the estimated reaction mechanism resulted in the inversion of enantioselectivity of arylmalonate decarboxylase, which catalyses the asymmetric decarboxylation of arylmethylmalonate to give optically active arylpropionate.

本文言語	English
ページ（範囲）	877-879
ページ数	3
ジャーナル	Chemical Communications
号	7
DOI	https://doi.org/10.1039/b416398b
出版ステータス	Published - 2005 2月 21

ASJC Scopus subject areas

電子材料、光学材料、および磁性材料
セラミックおよび複合材料
金属および合金
材料化学
表面、皮膜および薄膜
化学 (全般)
触媒

文献へのアクセス

10.1039/b416398b

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引用スタイル

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abstract = "The introduction of two mutations (G74C/C188S) based on the estimated reaction mechanism resulted in the inversion of enantioselectivity of arylmalonate decarboxylase, which catalyses the asymmetric decarboxylation of arylmethylmalonate to give optically active arylpropionate.",

author = "Yoichiro Ijima and Kaori Matoishi and Yosuke Terao and Nobuhide Doi and Hiroshi Yanagawa and Hiromichi Ohta",

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AU - Doi, Nobuhide

AU - Yanagawa, Hiroshi

AU - Ohta, Hiromichi

PY - 2005/2/21

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