TY - JOUR
T1 - Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates
AU - Okano, Hideyuki
AU - Kishi, Noriyuki
N1 - Funding Information:
We thank Dr. Erika Sasaki and Dr. Kenya Sato for their contributions to their original work on GM marmosets. We apologize to colleagues whose works were not mentioned due to space limitations. This work is supported by Brain/MINDS and the Strategic Research Program for Brain Sciences from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT) and Japan Agency for Medical Research and Development (AMED) . H.O. is a paid Scientific Advisory Board of SanBio Co Ltd and K Pharma Inc.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/6
Y1 - 2018/6
N2 - Although mice have been the most frequently used experimental animals in many research fields due to well-established gene manipulation techniques, recent evidence has revealed that rodent models do not always recapitulate pathophysiology of human neurological and psychiatric diseases due to the differences between humans and rodents. The recent developments in gene manipulation of non-human primate have been attracting much attention in the biomedical research field, because non-human primates have more applicable brain structure and function than rodents. In this review, we summarize recent progress on genetically-modified non-human primates including transgenic and knockout animals using genome editing technology.
AB - Although mice have been the most frequently used experimental animals in many research fields due to well-established gene manipulation techniques, recent evidence has revealed that rodent models do not always recapitulate pathophysiology of human neurological and psychiatric diseases due to the differences between humans and rodents. The recent developments in gene manipulation of non-human primate have been attracting much attention in the biomedical research field, because non-human primates have more applicable brain structure and function than rodents. In this review, we summarize recent progress on genetically-modified non-human primates including transgenic and knockout animals using genome editing technology.
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U2 - 10.1016/j.conb.2017.10.016
DO - 10.1016/j.conb.2017.10.016
M3 - Review article
C2 - 29125958
AN - SCOPUS:85032909608
SN - 0959-4388
VL - 50
SP - 1
EP - 6
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -
