IRBIT: A regulator of ion channels and ion transporters

Hideaki Ando, Katsuhiro Kawaai, Katsuhiko Mikoshiba

研究成果: Review article査読

38 被引用数 (Scopus)


IRBIT (also called AHCYL1) was originally identified as a binding protein of the intracellular Ca2+ channel inositol 1,4,5-trisphosphate (IP3) receptor and functions as an inhibitory regulator of this receptor. Unexpectedly, many functions have subsequently been identified for IRBIT including the activation of multiple ion channels and ion transporters, such as the Na+/HCO3- co-transporter NBCe1-B, the Na+/H+ exchanger NHE3, the Cl- channel cystic fibrosis transmembrane conductance regulator (CFTR), and the Cl-/HCO3- exchanger Slc26a6. The characteristic serine-rich region in IRBIT plays a critical role in the functions of this protein. In this review, we describe the evolution, domain structure, expression pattern, and physiological roles of IRBIT and discuss the potential molecular mechanisms underlying the coordinated regulation of these diverse ion channels/transporters through IRBIT. This article is part of a Special Issue entitled: Calcium signaling in health and disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.

ジャーナルBiochimica et Biophysica Acta - Molecular Cell Research
出版ステータスPublished - 2014 10月

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学


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