TY - JOUR
T1 - Irijimasides A-E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium
AU - Yamano, Aki
AU - Natsume, Noriyuki
AU - Yamada, Miki
AU - Sumimoto, Shimpei
AU - Iwasaki, Arihiro
AU - Suenaga, Kiyotake
AU - Teruya, Toshiaki
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Young Scientists (B) (15K01803) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and a University of the Ryukyus Strategic Research Grant.
Publisher Copyright:
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy.
PY - 2020/5/22
Y1 - 2020/5/22
N2 - Irijimasides A-E (1-5), a series of new 14-membered macrolide glycosides, were isolated from a marine cyanobacterium collected in Okinawa. The gross structures of 1-5 were established by spectroscopic analysis, including 2D NMR, while absolute stereostructures were determined based on NOESY spectra, chemical derivatization, and ECD data. All five macrolides suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity in mouse RAW264 macrophage cells, indicating that these compounds inhibit osteoclast formation.
AB - Irijimasides A-E (1-5), a series of new 14-membered macrolide glycosides, were isolated from a marine cyanobacterium collected in Okinawa. The gross structures of 1-5 were established by spectroscopic analysis, including 2D NMR, while absolute stereostructures were determined based on NOESY spectra, chemical derivatization, and ECD data. All five macrolides suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity in mouse RAW264 macrophage cells, indicating that these compounds inhibit osteoclast formation.
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U2 - 10.1021/acs.jnatprod.0c00042
DO - 10.1021/acs.jnatprod.0c00042
M3 - Article
C2 - 32267694
AN - SCOPUS:85083226811
SN - 0163-3864
VL - 83
SP - 1585
EP - 1591
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -
