TY - JOUR
T1 - Iron-Catalyzed Ortho C-H Homoallylation of Aromatic Ketones with Methylenecyclopropanes
AU - Kimura, Naoki
AU - Katta, Shiori
AU - Kitazawa, Yoichi
AU - Kochi, Takuya
AU - Kakiuchi, Fumitoshi
N1 - Publisher Copyright:
©
PY - 2021/3/31
Y1 - 2021/3/31
N2 - We report here a C-H homoallylation reaction of aromatic ketones with methylenecyclopropanes (MCPs) only using a catalytic amount of Fe(PMe3)4. A variety of aromatic ketones and MCPs are applicable to the reaction to form ortho-homoallylated aromatic ketones selectively via regioselective scission of the three-membered rings. The homoallylated products are amenable to further elaborations, providing functionalized 1,2-dihydronaphthalenes.
AB - We report here a C-H homoallylation reaction of aromatic ketones with methylenecyclopropanes (MCPs) only using a catalytic amount of Fe(PMe3)4. A variety of aromatic ketones and MCPs are applicable to the reaction to form ortho-homoallylated aromatic ketones selectively via regioselective scission of the three-membered rings. The homoallylated products are amenable to further elaborations, providing functionalized 1,2-dihydronaphthalenes.
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U2 - 10.1021/jacs.1c00237
DO - 10.1021/jacs.1c00237
M3 - Article
C2 - 33729786
AN - SCOPUS:85103509564
SN - 0002-7863
VL - 143
SP - 4543
EP - 4549
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 12
ER -