Isolation and Total Synthesis of Beru'amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp.

Raimu Taguchi; Arihiro Iwasaki; Akira Ebihara; Ghulam Jeelani; Tomoyoshi Nozaki; Kiyotake Suenaga

doi:10.1021/acs.orglett.2c02013

Isolation and Total Synthesis of Beru'amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp.

Raimu Taguchi, Arihiro Iwasaki, Akira Ebihara, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

化学科

研究成果: Article › 査読

2 被引用数 (Scopus)

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A 68 μg amount of an acyclic polyketide, named beru'amide, was isolated from a marine cyanobacterium Okeania sp. Beru'amide contains six unique moieties in its relatively small skeleton. By applying several cutting-edge techniques, including DFT-based chemical shift calculations, we achieved the structure determination and the total synthesis of this highly functionalized scarce natural product. Furthermore, beru'amide was shown to have strong antitrypanosomal activity. 2022 American Chemical Society.

本文言語	English
ページ（範囲）	4710-4714
ページ数	5
ジャーナル	Organic Letters
巻	24
号	25
DOI	https://doi.org/10.1021/acs.orglett.2c02013
出版ステータス	Published - 2022 7月 1

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

UN SDG

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10.1021/acs.orglett.2c02013

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title = "Isolation and Total Synthesis of Beru'amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp.",

abstract = "A 68 μg amount of an acyclic polyketide, named beru'amide, was isolated from a marine cyanobacterium Okeania sp. Beru'amide contains six unique moieties in its relatively small skeleton. By applying several cutting-edge techniques, including DFT-based chemical shift calculations, we achieved the structure determination and the total synthesis of this highly functionalized scarce natural product. Furthermore, beru'amide was shown to have strong antitrypanosomal activity. 2022 American Chemical Society.",

author = "Raimu Taguchi and Arihiro Iwasaki and Akira Ebihara and Ghulam Jeelani and Tomoyoshi Nozaki and Kiyotake Suenaga",

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AU - Ebihara, Akira

AU - Jeelani, Ghulam

AU - Nozaki, Tomoyoshi

AU - Suenaga, Kiyotake

N1 - Funding Information: This work was supported by JSPS KAKENHI Grant No. 18K14346, 20H02870 and the Keio Gijuku Academic Development Funds. Publisher Copyright: © 2022 American Chemical Society. All rights reserved.

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N2 - A 68 μg amount of an acyclic polyketide, named beru'amide, was isolated from a marine cyanobacterium Okeania sp. Beru'amide contains six unique moieties in its relatively small skeleton. By applying several cutting-edge techniques, including DFT-based chemical shift calculations, we achieved the structure determination and the total synthesis of this highly functionalized scarce natural product. Furthermore, beru'amide was shown to have strong antitrypanosomal activity. 2022 American Chemical Society.

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Isolation and Total Synthesis of Beru'amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp.

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ASJC Scopus subject areas

UN SDG

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