Isolation and Total Synthesis of Kinenzoline, an Antitrypanosomal Linear Depsipeptide Isolated from a Marine Salileptolyngbya sp. Cyanobacterium

Naoaki Kurisawa; Keisuke Otomo; Arihiro Iwasaki; Ghulam Jeelani; Tomoyoshi Nozaki; Kiyotake Suenaga

doi:10.1021/acs.joc.1c00817

Isolation and Total Synthesis of Kinenzoline, an Antitrypanosomal Linear Depsipeptide Isolated from a Marine Salileptolyngbya sp. Cyanobacterium

Naoaki Kurisawa, Keisuke Otomo, Arihiro Iwasaki, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga

化学科

研究成果: Article › 査読

5 被引用数 (Scopus)

抄録

Kinenzoline (1), a new linear depsipeptide, was isolated from a marine Salileptolyngbya sp. cyanobacterium. Its structure was elucidated by spectroscopic analyses and degradation reactions. In addition, we achieved a total synthesis of 1 and confirmed its structure. Kinenzoline (1) showed highly selective antiproliferative activity against the causative organism of sleeping sickness, Trypanosoma brucei rhodesiense (IC50 4.5 μM), compared to normal human cells (WI-38, IC50 > 100 μM). Kinenzoline (1) is a promising lead compound for the development of new antitrypanosomal drugs.

本文言語	English
ページ（範囲）	12528-12536
ページ数	9
ジャーナル	Journal of Organic Chemistry
巻	86
号	18
DOI	https://doi.org/10.1021/acs.joc.1c00817
出版ステータス	Published - 2021 9月 17

ASJC Scopus subject areas

有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1021/acs.joc.1c00817

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引用スタイル

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abstract = "Kinenzoline (1), a new linear depsipeptide, was isolated from a marine Salileptolyngbya sp. cyanobacterium. Its structure was elucidated by spectroscopic analyses and degradation reactions. In addition, we achieved a total synthesis of 1 and confirmed its structure. Kinenzoline (1) showed highly selective antiproliferative activity against the causative organism of sleeping sickness, Trypanosoma brucei rhodesiense (IC50 4.5 μM), compared to normal human cells (WI-38, IC50 > 100 μM). Kinenzoline (1) is a promising lead compound for the development of new antitrypanosomal drugs.",

author = "Naoaki Kurisawa and Keisuke Otomo and Arihiro Iwasaki and Ghulam Jeelani and Tomoyoshi Nozaki and Kiyotake Suenaga",

note = "Funding Information: This work was supported by JSPS KAKENHI (Grant Numbers 18K14346, 20H02870, and 21J13608) and Keio Gijuku Academic Development Funds. Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

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AU - Kurisawa, Naoaki

AU - Otomo, Keisuke

AU - Iwasaki, Arihiro

AU - Jeelani, Ghulam

AU - Nozaki, Tomoyoshi

AU - Suenaga, Kiyotake

N1 - Funding Information: This work was supported by JSPS KAKENHI (Grant Numbers 18K14346, 20H02870, and 21J13608) and Keio Gijuku Academic Development Funds. Publisher Copyright: © 2021 American Chemical Society.

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