Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

Keiji Yuki; Mariko Ikeda; Kenji Miyamoto; Osamu Ohno; Kaoru Yamada; Daisuke Uemura

doi:10.1271/bbb.110994

Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

Keiji Yuki, Mariko Ikeda, Kenji Miyamoto, Osamu Ohno, Kaoru Yamada, Daisuke Uemura

生命情報学科

研究成果: Article › 査読

6 被引用数 (Scopus)

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An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

本文言語	English
ページ（範囲）	1233-1235
ページ数	3
ジャーナル	Bioscience, Biotechnology and Biochemistry
巻	76
号	6
DOI	https://doi.org/10.1271/bbb.110994
出版ステータス	Published - 2012

ASJC Scopus subject areas

バイオテクノロジー
分析化学
生化学
応用微生物学とバイオテクノロジー
分子生物学
有機化学

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10.1271/bbb.110994

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title = "Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei",

abstract = "An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.",

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AU - Yuki, Keiji

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AU - Miyamoto, Kenji

AU - Ohno, Osamu

AU - Yamada, Kaoru

AU - Uemura, Daisuke

PY - 2012

Y1 - 2012

N2 - An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

AB - An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

KW - 3T3-L1 murine adipocytes

KW - Fat accumulation

KW - Inhibitor

KW - Valeriana fauriei

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

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Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

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