Isolation of a new indole alkaloid, pendolmycin, from nocardiopsis

Takashi Yamashita; Masaya Imoto; Kunio Isshiki; Tsutomu Sawa; Hiroshi Naganawa; Shogo Kurasawa; Kazuo Umezawa; Bao Quan Zhu

doi:10.1021/np50060a022

Isolation of a new indole alkaloid, pendolmycin, from nocardiopsis

Takashi Yamashita, Masaya Imoto, Kunio Isshiki, Tsutomu Sawa, Hiroshi Naganawa, Shogo Kurasawa, Kazuo Umezawa, Bao Quan Zhu

研究成果: Article › 査読

26 被引用数 (Scopus)

抄録

—A new indole alkaloid, pendolmycin {1}, was isolated from NocardioPsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turn-over in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B {2} and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.

本文言語	English
ページ（範囲）	1184-1187
ページ数	4
ジャーナル	Journal of Natural Products
巻	51
号	6
DOI	https://doi.org/10.1021/np50060a022
出版ステータス	Published - 1988 11月
外部発表	はい

ASJC Scopus subject areas

分析化学
分子医療
薬理学
薬科学
創薬
補完代替医療
有機化学

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10.1021/np50060a022

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AU - Yamashita, Takashi

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AU - Isshiki, Kunio

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AU - Naganawa, Hiroshi

AU - Kurasawa, Shogo

AU - Umezawa, Kazuo

AU - Zhu, Bao Quan

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AB - —A new indole alkaloid, pendolmycin {1}, was isolated from NocardioPsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turn-over in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B {2} and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.

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Isolation of a new indole alkaloid, pendolmycin, from nocardiopsis

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