Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

Chino Matsui; Yoko Ikeda; Hironobu Iinuma; Nobuaki Kushida; Takao Kunisada; Siro Simizu; Kazuo Umezawa

doi:10.1038/ja.2014.63

Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

Chino Matsui, Yoko Ikeda, Hironobu Iinuma, Nobuaki Kushida, Takao Kunisada, Siro Simizu, Kazuo Umezawa

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研究成果: Article › 査読

12 被引用数 (Scopus)

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We have screened microbial culture filtrates for nitrogen monoxide (NO) production inhibitors using mouse macrophage cell line RAW264.7. As a result, paxilline, 21-isopentenylpaxilline and a novel analog of paxilline have been isolated from the culture filtrate of fungus Eupenicillium shearii. The novel analog possesses an additional dihydropyran ring, and was named as pyrapaxilline. This compound inhibited the NO production with lower toxicity than paxilline.

本文言語	English
ページ（範囲）	787-790
ページ数	4
ジャーナル	Journal of Antibiotics
巻	67
号	11
DOI	https://doi.org/10.1038/ja.2014.63
出版ステータス	Published - 2014 11月 1

ASJC Scopus subject areas

薬理学
創薬

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10.1038/ja.2014.63

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AU - Kushida, Nobuaki

AU - Kunisada, Takao

AU - Simizu, Siro

AU - Umezawa, Kazuo

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AB - We have screened microbial culture filtrates for nitrogen monoxide (NO) production inhibitors using mouse macrophage cell line RAW264.7. As a result, paxilline, 21-isopentenylpaxilline and a novel analog of paxilline have been isolated from the culture filtrate of fungus Eupenicillium shearii. The novel analog possesses an additional dihydropyran ring, and was named as pyrapaxilline. This compound inhibited the NO production with lower toxicity than paxilline.

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Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

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