@article{a7f52a186af94f7e85f1e6ca3c8323ff,
title = "Isolation of Caldorazole, a Thiazole-Containing Polyketide with Selective Cytotoxicity under Glucose-Restricted Conditions",
abstract = "Caldorazole (1) was isolated from the marine cyanobacterium Caldora sp. collected on Ishigaki Island, Okinawa, Japan. Its structure was determined to be a new polyketide that contained two thiazole rings and an O-methylenolpyruvamide moiety. Caldorazole (1) showed strong cytotoxicity toward tumor cells that had been seeded at a high density. Cell death induced by 1 in HeLa and A431 cells was also observed only in the presence of the glycolysis blocker 2-deoxy-d-glucose (2DG). Co-treatment with 1 and 2DG remarkably decreased ATP levels in these cells. Furthermore, 1 selectively inhibited complex I in the mitochondrial respiratory chain. Thus, 1 was demonstrated to exert cytotoxicity toward human tumor cells by blocking mitochondrial respiration. 2022 American Chemical Society.",
author = "Osamu Ohno and Arihiro Iwasaki and Kyouhei Same and Chihiro Kudo and Erika Aida and Kazuya Sugiura and Shimpei Sumimoto and Toshiaki Teruya and Etsu Tashiro and Siro Simizu and Kenji Matsuno and Masaya Imoto and Kiyotake Suenaga",
note = "Funding Information: The authors thank Prof. Hideaki Kakeya (Kyoto University, Kyoto, Japan) and Prof. Shoichiro Suda (University of the Ryukyus) for their contributions to our studies. This work was supported by Grants-in-Aid for Scientific Research (21K05295 and 24310160) and in part by a grant for the Strategic Research Foundation Grant-aided Project for Private Universities (S1411005) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors thank the Shorai Foundation for Science and Technology for their financial support. Publisher Copyright: {\textcopyright} 2022 American Chemical Society. All rights reserved.",
year = "2022",
month = jul,
day = "1",
doi = "10.1021/acs.orglett.2c01566",
language = "English",
volume = "24",
pages = "4547--4551",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "25",
}
