TY - JOUR
T1 - ISOLATION of PEPTIDOLIPIN NA DERIVATIVES from the CULTURE of NOCARDIA ARTHRITIDIS IFM10035T in the PRESENCE of MOUSE MACROPHAGE CELLS
AU - Hara, Yasumasa
AU - Tanimura, Daiki
AU - Manome, Teruhisa
AU - Arai, Midori A.
AU - Yaguchi, Takashi
AU - Ishibashi, Masami
N1 - Publisher Copyright:
© 2022 The Japan Institute of Heterocyclic Chemistry.
PY - 2021
Y1 - 2021
N2 - We isolated two peptidolipin NA derivatives, L-Val (6) peptidolipin NA and peptidolipin NA, named as compounds 1 and 2, respectively. These compounds were produced in the co-culture extracts of Nocardia arthritidis IFM10035T and the mouse macrophage cell line J774.1, but not in the single culture of N. arthritidis. Among the two compounds along with nocarjamide (3) isolated from the co-culture of N. tenerifensis and J774.1, compounds 1 and 3 showed higher cytotoxicity against J774.1, with IC50 values of 116 μM and 25 μM, respectively. In addition, compound 1 showed a TRAIL-resistance-overcoming activity in the human gastric adenocarcinoma AGS cells.
AB - We isolated two peptidolipin NA derivatives, L-Val (6) peptidolipin NA and peptidolipin NA, named as compounds 1 and 2, respectively. These compounds were produced in the co-culture extracts of Nocardia arthritidis IFM10035T and the mouse macrophage cell line J774.1, but not in the single culture of N. arthritidis. Among the two compounds along with nocarjamide (3) isolated from the co-culture of N. tenerifensis and J774.1, compounds 1 and 3 showed higher cytotoxicity against J774.1, with IC50 values of 116 μM and 25 μM, respectively. In addition, compound 1 showed a TRAIL-resistance-overcoming activity in the human gastric adenocarcinoma AGS cells.
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U2 - 10.3987/COM-21-14567
DO - 10.3987/COM-21-14567
M3 - Article
AN - SCOPUS:85122212206
SN - 0385-5414
VL - 104
SP - 185
EP - 190
JO - Heterocycles
JF - Heterocycles
IS - 1
ER -