TY - JOUR
T1 - Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium
AU - Kanamori, Yuki
AU - Iwasaki, Arihiro
AU - Sumimoto, Shimpei
AU - Matsubara, Teruhiko
AU - Sato, Toshinori
AU - Suenaga, Kiyotake
N1 - Publisher Copyright:
© 2018 American Chemical Society and American Society of Pharmacognosy.
PY - 2018/7/27
Y1 - 2018/7/27
N2 - Izenamides A, B, and C (1-3), new linear depsipeptides, were isolated from a taxonomically distinct marine cyanobacterium. Izenamides A and B contain a statine moiety [(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid] and inhibited the activity of cathepsin D, an aspartic peptidase. Meanwhile, izenamides did not show growth-inhibitory activity against HeLa, HL60, or MCF-7 cells at up to 10 μM.
AB - Izenamides A, B, and C (1-3), new linear depsipeptides, were isolated from a taxonomically distinct marine cyanobacterium. Izenamides A and B contain a statine moiety [(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid] and inhibited the activity of cathepsin D, an aspartic peptidase. Meanwhile, izenamides did not show growth-inhibitory activity against HeLa, HL60, or MCF-7 cells at up to 10 μM.
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U2 - 10.1021/acs.jnatprod.8b00417
DO - 10.1021/acs.jnatprod.8b00417
M3 - Article
C2 - 29944370
AN - SCOPUS:85050779518
SN - 0163-3864
VL - 81
SP - 1673
EP - 1681
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 7
ER -
