抄録
Biological
| 本文言語 | English |
|---|---|
| 論文番号 | 101479 |
| ジャーナル | iScience |
| 巻 | 23 |
| 号 | 9 |
| DOI | |
| 出版ステータス | Published - 2020 9月 25 |
ASJC Scopus subject areas
- 一般
フィンガープリント
「Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。引用スタイル
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In: iScience, Vol. 23, No. 9, 101479, 25.09.2020.
研究成果: Article › 査読
}
TY - JOUR
T1 - Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes
AU - Ohno, Satoshi
AU - Quek, Lake Ee
AU - Krycer, James R.
AU - Yugi, Katsuyuki
AU - Hirayama, Akiyoshi
AU - Ikeda, Satsuki
AU - Shoji, Futaba
AU - Suzuki, Kumi
AU - Soga, Tomoyoshi
AU - James, David E.
AU - Kuroda, Shinya
N1 - Funding Information: We are grateful to Dr. Shinsuke Uda, Dr. Hiroyuki Kubota, Dr. Fumio Matsuda, Dr. Hiroshi Shimizu, Dr. Yoshihiro Toya, and our laboratory members for fruitful discussion. We thank Nancy R. Gough, BioSerendipity, LLC, for writing and editorial assistance. The computational analysis of this work was performed in part with support of the super computer system of National Institute of Genetics (NIG), Research Organization of Information and Systems (ROIS). This research was facilitated by access to Sydney Mass Spectrometry, a core research facility at the University of Sydney. This work was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST (JPMJCR12W3) from the Japan Science and Technology Agency (JST), and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number (17H06300, 17H06299, 18H03979). S.O. was funded by JSPS KAKENHI Grant Number JP17K14864. L.-E.Q. was funded by the Judith and David Coffey Fund, and Cancer Institute NSW. J.R.K. was funded by an NHMRC Early Career Fellowship (APP1072440), Australian Diabetes Society Skip Martin Early Career Fellowship, and Diabetes Australia Research grant. D.E.J. is an NHMRC Senior Principal Research Fellow (APP1019680). K.Y. was funded by JSPS KAKENHI Grant Number JP15H05582 and JP18H05431, and ‘‘Creation of Innovative Technology for Medical Applications Based on the Global Analyses and Regulation of Disease-Related Metabolites,” PRESTO (JPMJPR1538) from JST. A.H. was funded by the Research on Development of New Drugs (GAPFREE) from the Japan Agency for Medical Research and Development, AMED. T.S. was funded by the AMED-CREST from AMED. A.H. and T.S. were funded from Yamagata prefectural government and the City of Tsuruoka. S.O. D.E.J. and S.K. conceived the project. S.O. performed the modeling. L.-E.Q. J.R.K. A.H. S.I. F.S. K.S. and T.S. performed experiments. S.O. L.-E.Q. K.Y. and J.R.K. analyzed the data. S.O. and S.K. wrote the manuscript. All authors read and approved the final manuscript. The authors declare no competing interests. Funding Information: This work was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST ( JPMJCR12W3 ) from the Japan Science and Technology Agency (JST), and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number ( 17H06300 , 17H06299 , 18H03979 ). S.O. was funded by JSPS KAKENHI Grant Number JP17K14864 . L.-E.Q. was funded by the Judith and David Coffey Fund, and Cancer Institute NSW . J.R.K. was funded by an NHMRC Early Career Fellowship ( APP1072440 ), Australian Diabetes Society Skip Martin Early Career Fellowship, and Diabetes Australia Research grant. D.E.J. is an NHMRC Senior Principal Research Fellow ( APP1019680 ). K.Y. was funded by JSPS KAKENHI Grant Number JP15H05582 and JP18H05431 , and ‘‘Creation of Innovative Technology for Medical Applications Based on the Global Analyses and Regulation of Disease-Related Metabolites,” PRESTO ( JPMJPR1538 ) from JST. A.H. was funded by the Research on Development of New Drugs (GAPFREE) from the Japan Agency for Medical Research and Development , AMED. T.S. was funded by the AMED-CREST from AMED . A.H. and T.S. were funded from Yamagata prefectural government and the City of Tsuruoka. Publisher Copyright: © 2020 The Author(s)
PY - 2020/9/25
Y1 - 2020/9/25
N2 - Biological
AB - Biological
KW - Biological Sciences
KW - Mathematical Biosciences
KW - Metabolic Flux Analyisis
KW - Metabolomics
KW - Omics
KW - Proteomics
KW - Systems Biology
UR - http://www.scopus.com/inward/record.url?scp=85090116649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090116649&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2020.101479
DO - 10.1016/j.isci.2020.101479
M3 - Article
AN - SCOPUS:85090116649
SN - 2589-0042
VL - 23
JO - iScience
JF - iScience
IS - 9
M1 - 101479
ER -