@article{8cdc391601dd449eb08c99f0f38ca100,
title = "Ktedonoketone and 2{\textquoteright}-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi",
abstract = "A thermophilic bacterium Thermosporothrix hazakensis NBRC 105916 which belongs to the class Ktedonobacteria was investigated to explore its biosynthetic potential of secondary metabolites. UV-guided fractionation led to the identification of a new benzenoid metabolite designated ktedonoketone (6) and an α-diketone metabolite 2{\textquoteright}-oxosattabacin (7) along with five known compounds. Compound 7 was previously described as a synthetic compound, but this is the first finding as a natural product. Compound 7 induced adipocyte differentiation at 10–20 μM and autophagy at 1–10 μM. Compound 6 showed weak inducing activity of adipocyte differentiation. The biosynthetic origin of hazakacin (3), an acyloin-type compound, was elucidated by 13C-labeled precursor-feeding experiments.",
author = "Yasuhiro Igarashi and Kazuki Yamamoto and Chiaki Ueno and Nodoka Yamada and Katsuya Saito and Kazuki Takahashi and Masaru Enomoto and Shigefumi Kuwahara and Tsutomu Oikawa and Etsu Tashiro and Masaya Imoto and Ye Xiaohanyao and Tao Zhou and Enjuro Harunari and Naoya Oku",
note = "Funding Information: Acknowledgements We thank to Dr. T. Okuda and Ms. Y. Sudoh for antimicrobial assay. This work was supported by JSPS KAKENHI Grant Number 24580156 to Y. I. Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.",
year = "2019",
month = sep,
day = "1",
doi = "10.1038/s41429-019-0195-7",
language = "English",
volume = "72",
pages = "653--660",
journal = "Journal of Antibiotics",
issn = "0021-8820",
publisher = "Japan Antibiotics Research Association",
number = "9",
}