Kynurenine pathway in depression: A systematic review and meta-analysis

Kamiyu Ogyu, Kaoruhiko Kubo, Yoshihiro Noda, Yusuke Iwata, Sakiko Tsugawa, Yuki Omura, Masataka Wada, Ryosuke Tarumi, Eric Plitman, Sho Moriguchi, Takahiro Miyazaki, Hiroyuki Uchida, Ariel Graff-Guerrero, Masaru Mimura, Shinichiro Nakajima

研究成果: Review article査読

188 被引用数 (Scopus)


Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression. However, the relationships between depression and each metabolite of the KYN pathway remain uncertain. Therefore, we conducted a meta-analysis about the levels of the metabolites of KYN pathway between patients with depression and controls. Out of 899 initial records, we identified 22 articles to form the empirical basis. Seventeen, 10, and 18 studies examined levels of kynurenic acid (KYNA), quinolinic acid (QUIN), and KYN, respectively. KYNA and KYN levels were lower in patients with depression in comparison to controls, while QUIN levels did not differ between the two groups. Antidepressant-free patients showed decreased KYNA levels and increased QUIN levels compared with controls. Male ratios of the samples were negatively associated with study SMDs for KYNA. In conclusion, this meta-analysis revealed that patients with depression had decreased level of KYNA and KYN, whereas antidepressant-free patients showed increased level of QUIN. Nevertheless, given the heterogeneity among their sample characteristics, further research is clearly needed.

ジャーナルNeuroscience and Biobehavioral Reviews
出版ステータスPublished - 2018 7月

ASJC Scopus subject areas

  • 神経心理学および生理心理学
  • 認知神経科学
  • 行動神経科学


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