Laboratory and clinical studies on cefprozil granules in pediatrics

Hlronobu Akita, Yoshitake Sato, Satoshi Iwata, Keisuke Sunakawa

研究成果: Article査読


Fundamental and clinical effects of cefprozil (CFPZ, BMY-28100) granules, a new oral cephalosporin antibiotic, in pediatric field were investigated. The result obtained were summarized as follows. 1. CFPZ (10% granules) was given to 1 child in a single dose of 7.5 mgAg. The peak serum concentration of CFPZ was 4.51 μg/ml at 2 hours after administration. Half-life and AUC values were 0.98 hour and 20.7 μ The mean peak urinary concentrations of CFPZ and 6 hours recovery rates were over 200 μg/ml at 2-6 hours and 27.6%, respectively. 2. Clinical efficacy of CFPZ was investigated in a total of 41 children, including 14 with upper respiratory tract infections, 6 with acute bronchitis and pneumonia, 2 with acute otitis media, 3 with skin and soft tissue infections and 16 with urinary tract infections. The clinical efficacy rate was 95.1%. The bacteriological eradication rate was 84.6%. 3. Two patients showed abnormal laboratory test results. One had elevations of both GOT and GPT, and another had eosinophilia which were attributed to this antibiotic as side effects.

ジャーナルthe japanese journal of antibiotics
出版ステータスPublished - 1992 1月

ASJC Scopus subject areas

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症


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