Lipopeptides from Staphylococcus aureus as Tlr2 ligands: Prediction with mRNA expression, chemical synthesis, and immunostimulatory activities

Yukari Fujimoto; Masahito Hashimoto; Maiko Furuyashiki; Mami Katsumoto; Tsukasa Seya; Yasuo Suda; Koichi Fukase

doi:10.1002/cbic.200900242

Lipopeptides from Staphylococcus aureus as Tlr2 ligands: Prediction with mRNA expression, chemical synthesis, and immunostimulatory activities

Yukari Fujimoto, Masahito Hashimoto, Maiko Furuyashiki, Mami Katsumoto, Tsukasa Seya, Yasuo Suda, Koichi Fukase

研究成果: Article › 査読

18 被引用数 (Scopus)

抄録

(Chemical Equation Presented) Recognize this? Based on predictions from mRNA expression of lipoproteins from Staphylococcus aureus, lipopeptide fragments were chemically synthesized, and their TLR2-stimulatory activities and cytokine-induction capabilities were analyzed. All the lipopeptides activated TLR2, but the activities varied depending on their peptide sequences.

本文言語	English
ページ（範囲）	2311-2315
ページ数	5
ジャーナル	ChemBioChem
巻	10
号	14
DOI	https://doi.org/10.1002/cbic.200900242
出版ステータス	Published - 2009 9月 21
外部発表	はい

ASJC Scopus subject areas

生化学
分子医療
分子生物学
有機化学

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10.1002/cbic.200900242

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引用スタイル

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AU - Fukase, Koichi

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