Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates

Biochemistry, Genetics and Molecular Biology

• Superoxide Dismutase 100%
• SOD1 100%
• Dynamics 71%
• Wild Type 42%
• Protein Catabolism 14%
• Hydrogen Bond 14%

Keyphrases

• Local Unfolding 100%
• Folded Structure 28%
• Conformational Dynamics 14%
• Computational Study 14%
• Atomistic Molecular Dynamics Simulations 14%
• Unfolded Structure 14%
• Aggregation-prone 14%
• Backbone Hydrogen Bonds 14%
• Multiscale Simulation 14%
• Structure Form 14%
• Simulation Approach 14%
• Aggregate Morphology 14%