Longitudinal monitoring of circulating immune cell phenotypes in anti-neutrophil cytoplasmic antibody-associated vasculitis

Kotaro Matsumoto, Katsuya Suzuki, Hidekata Yasuoka, Junichi Hirahashi, Hiroto Yoshida, Mayu Magi, Mariko Noguchi-Sasaki, Yuko Kaneko, Tsutomu Takeuchi

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a necrotizing multiorgan autoimmune disease that affects small- to medium-sized blood vessels. Despite the improvements in treatments, half of the patients with AAV still experience disease relapses. In this review, we focus on peripheral leukocyte properties and phenotypes in patients with AAV. In particular, we explore longitudinal changes in circulating immune cell phenotypes during the active phase of the disease and treatment. The numbers and phenotypes of leukocytes in peripheral blood were differs between AAV and healthy controls, AAV in active versus inactive phase, AAV in treatment responders versus non-responders, and AAV with and without severe infection. Therefore, biomarkers detected in peripheral blood immune cells may be useful for longitudinal monitoring of disease activity in AAV.

本文言語English
論文番号103271
ジャーナルAutoimmunity Reviews
22
3
DOI
出版ステータスPublished - 2023 3月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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