Loss of heterozygosity analysis in malignant gliomas

Masahiro Mizoguchi, Daisuke Kuga, Yanlei Guan, Nobuhiro Hata, Akira Nakamizo, Koji Yoshimoto, Tomio Sasaki

研究成果: Article査読

22 被引用数 (Scopus)


Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers-such as loss of heterozygosity (LOH) on chromosome 1p/19q and chromosome 10, O6-methylguanine methyltransferase promoter hypermethylation, and mutation of isocitrate dehydrogenase-1-may help to predict patient outcomes. Indeed, LOH analysis is an effective approach to classify malignant gliomas. Genome-wide analyses have revealed that the extent and pattern of LOH regions may have important implications for the clinical course of the disease. As the genetic underpinnings of malignant gliomas are complex and varied, careful selection of the methods for genetic analysis in the clinic is important. The fundamental principles of each assay need to be understood to allow careful selection of practically useful methods. This review summarizes recent developments in the molecular analysis of malignant glioma.

ジャーナルBrain tumor pathology
出版ステータスPublished - 2011 7月

ASJC Scopus subject areas

  • 腫瘍学
  • 臨床神経学
  • 癌研究


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