@article{7f97a569f1ce4bfc9793000cee9ebd63,
title = "Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells",
abstract = "Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2. μM) and/or valproic acid (5. mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.",
keywords = "Autophagy, Cell invasion, Lovastatin, Mesothelioma, Valproic acid",
author = "Yoshikane Yamauchi and Yotaro Izumi and Keisuke Asakura and Toshinori Fukutomi and Akihiko Serizawa and Kenji Kawai and Masatoshi Wakui and Makoto Suematsu and Hiroaki Nomori",
note = "Funding Information: We thank Kei Tsujioka, Division of General Thoracic Surgery, for excellent technical assistance. This work was supported in part by grant in aid from the Ministry of Education, Culture, Sports, Science, and Technology-Japan to KA (No. 19790981 ), in part by Global COE Program for Metabolomics Systems Biology from the Ministry of Education, Culture, Sports, Science and Technology to MS, and in part by School of Medicine, Keio University fund for the promotion of science to MW and YI.",
year = "2011",
month = jul,
day = "1",
doi = "10.1016/j.bbrc.2011.05.149",
language = "English",
volume = "410",
pages = "328--332",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",
}
