TY - JOUR
T1 - Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
AU - Kanai, Takanori
AU - Uraushihara, Koji
AU - Totsuka, Teruji
AU - Okazawa, Akira
AU - Hibi, Toshifumi
AU - Oshima, Shigeru
AU - Miyata, Tatsuya
AU - Nakamura, Tetsuya
AU - Watanabe, Mamoru
PY - 2003/6
Y1 - 2003/6
N2 - Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha, macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophage-derived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.
AB - Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha, macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophage-derived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.
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U2 - 10.2174/1568010033484250
DO - 10.2174/1568010033484250
M3 - Review article
C2 - 14561165
AN - SCOPUS:0642344946
SN - 1568-010X
VL - 2
SP - 131
EP - 136
JO - Current drug targets. Inflammation and allergy
JF - Current drug targets. Inflammation and allergy
IS - 2
ER -