Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

Arihiro Iwasaki; Osamu Ohno; Shinpei Sumimoto; Shoichiro Suda; Kiyotake Suenaga

doi:10.1016/j.tetlet.2014.05.099

Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

Arihiro Iwasaki
, Osamu Ohno
, Shinpei Sumimoto
, Shoichiro Suda
, Kiyotake Suenaga

化学科

研究成果: Article › 査読

23 被引用数 (Scopus)

抄録

Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

本文言語	English
ページ（範囲）	4126-4128
ページ数	3
ジャーナル	Tetrahedron Letters
巻	55
号	30
DOI	https://doi.org/10.1016/j.tetlet.2014.05.099
出版ステータス	Published - 2014 7月 23

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

SDG 14 海の豊かさを守ろう

ASJC Scopus subject areas

生化学
創薬
有機化学

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10.1016/j.tetlet.2014.05.099

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引用スタイル

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title = "Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.",

abstract = "Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.",

keywords = "Chymotrypsin inhibitor, Depsipeptide, Lyngbya, Maedamide, Marine cyanobacteria",

author = "Arihiro Iwasaki and Osamu Ohno and Shinpei Sumimoto and Shoichiro Suda and Kiyotake Suenaga",

note = "Funding Information: This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( 24310160 and 25750386 ) and the MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2009–2013 from the Ministry of Education, Culture, Sports, Science and Technology, Japan. ",

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day = "23",

doi = "10.1016/j.tetlet.2014.05.099",

language = "English",

volume = "55",

pages = "4126--4128",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

AU - Iwasaki, Arihiro

AU - Ohno, Osamu

AU - Sumimoto, Shinpei

AU - Suda, Shoichiro

AU - Suenaga, Kiyotake

N1 - Funding Information: This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( 24310160 and 25750386 ) and the MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2009–2013 from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2014/7/23

Y1 - 2014/7/23

N2 - Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

AB - Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells.

KW - Chymotrypsin inhibitor

KW - Depsipeptide

KW - Lyngbya

KW - Maedamide

KW - Marine cyanobacteria

UR - https://www.scopus.com/pages/publications/84904048995

UR - https://www.scopus.com/pages/publications/84904048995#tab=citedBy

U2 - 10.1016/j.tetlet.2014.05.099

DO - 10.1016/j.tetlet.2014.05.099

M3 - Article

AN - SCOPUS:84904048995

SN - 0040-4039

VL - 55

SP - 4126

EP - 4128

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 30

ER -

Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.

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UN SDG

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