TY - CHAP
T1 - MD simulations on the structure of onco-proteins P53
T2 - Wild-type and radioresistant mutant systems
AU - Kholmurodov, Kholmirzo T.
AU - Krasavin, Evgenii A.
AU - Krylov, Viktor A.
AU - Dushanov, Ermuhammad B.
AU - Korenkov, Vladimir V.
AU - Yasuoka, Kenji
AU - Narumi, Tetsu
AU - Ohno, Yousuke
AU - Taiji, Makoto
AU - Ebisuzaki, Toshikazu
N1 - Publisher Copyright:
© 2017 Nova Science Publishers, Inc. All rights reserved.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Based on molecular dynamics (MD) simulation, a comparative analysis has been performed of the p53 dimer - DNA interaction for the wildtype and mutant Arg273His (R273H) proteins. The aim of this paper is to study the molecular mechanism of the p53 onco-protein and DNA binding. A comparative analysis shows that the R273H mutation has a significant effect on the p53-DNA interaction removing their close contact. The obtained MD simulation results illustrate in detail the molecular mechanism of the conformations of the key amino acids in the p53-DNA binding domain, which is important for the physiological functioning of the p53 protein and understanding the origin of cancer.
AB - Based on molecular dynamics (MD) simulation, a comparative analysis has been performed of the p53 dimer - DNA interaction for the wildtype and mutant Arg273His (R273H) proteins. The aim of this paper is to study the molecular mechanism of the p53 onco-protein and DNA binding. A comparative analysis shows that the R273H mutation has a significant effect on the p53-DNA interaction removing their close contact. The obtained MD simulation results illustrate in detail the molecular mechanism of the conformations of the key amino acids in the p53-DNA binding domain, which is important for the physiological functioning of the p53 protein and understanding the origin of cancer.
KW - MD simulations
KW - Onco-protein p53
KW - p53R273H mutation
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M3 - Chapter
AN - SCOPUS:85047936349
SN - 9781613243206
SP - 179
EP - 208
BT - Molecular Dynamics of Nanobiostructures
PB - Nova Science Publishers, Inc.
ER -
