Mechanisms underlying enhanced noradrenaline-induced femoral arterial contractions of spontaneously hypertensive rats: Involvement of endothelium-derived factors and cyclooxygenase-derived prostanoids

Takayuki Matsumoto, Shun Watanabe, Maika Iguchi, Makoto Ando, Mirai Oda, Mako Nagata, Kosuke Yamada, Kumiko Taguchi, Tsuneo Kobayashi

研究成果: Article査読

12 被引用数 (Scopus)

抄録

We investigated the relationship between noradrenaline (NAd)-induced contractions, endothelial function, and hypertension in femoral arteries isolated from spontaneously hypertensive rats (SHR). In the femoral arteries of SHR, vs. age-matched control Wistar Kyoto (WKY) rats, contractions induced by NAd were increased. These effects were enhanced by endothelial denudation, which abolished the differences between the two groups. NAd-induced contractions were enhanced by nitric oxide (NO) synthase inhibition, and further increased by the blockade of endothelium-derived hyperpolarizing factor (EDHF). Conversely, NAd-induced contractions were inhibited by cyclooxygenase (COX) inhibition. In addition, in SHR arteries, acetylcholine-induced relaxation was reduced, and components of endothelium-derived factors were altered, such as increased COX-derived vasoconstrictor prostanoids, reduced EDHF, and preserved NO-mediated relaxation. In the femoral arteries of SHR, the production of prostanoids [6-keto prostaglandin (PG)F1a (a metabolite of prostacyclin (PGI2), PGE2, and PGF2a] and COX-2 protein were increased compared with that in WKY rats. By contrast, contractions induced by beraprost (a stable PGI2 analogue), PGE2, and U46619 (thromboxane/prostanoid receptor agonist) were similar between the SHR and WKY groups. Thus, NAdinduced femoral arterial contractions are augmented in SHR resulting from endothelial dysfunction and increased COX-derived vasoconstrictor prostanoid levels.

本文言語English
ページ(範囲)384-393
ページ数10
ジャーナルBiological and Pharmaceutical Bulletin
39
3
DOI
出版ステータスPublished - 2016 3月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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