Meroterpenoids produced by Pseudocosmospora sp. Bm-1-1 isolated from Acanthus ebracteatus Vahl

Tomoki Nakamura, Takuma Suzuki, Nanang Rudianto Ariefta, Takuya Koseki, Takako Aboshi, Tetsuya Murayama, Ari Widiyantoro, Rikhsan Kurniatuhadi, Abdul Malik, Suwardi Annas, Desi Harneti, Rani Maharani, Unang Supratman, Junpei Abe, Naoaki Kurisawa, Ken ich Kimura, Yoshihito Shiono

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Fractionation of ethyl acetate extract obtained by culturing the endophytic fungus Pseudocosmospora sp. Bm-1-1 resulted in the isolation of four new meroterpenoids, cosmosporin A (1), 6-carboxy-cosmosporin A (2), rel-(6aS,10aR)-Δ 9 -tetrahydrocannabiorcolic acid B (3) and 8′-hydroxy-cannabiorcichromenic acid (4), in addition to four known compounds 5–8. Structures were elucidated by spectral analysis, as well as by directly comparing the spectral data of new compounds with those of known compounds. Cannabiorcichromenic acid (5), decarboxy-cannabiorcichromenic acid (6), and rel-(6aS,10aR)-decarboxy-Δ 9 -tetrahydrocannabiorcolic acid B (8) restored growth of a Saccharomyces cerevisiae mutant strain involving Ca 2+ signal transduction. Furthermore, compounds 3 and 8 had cytotoxic activity against HL60 cells (3: IC 50 = 24.1 μM and 8: IC 50 1.6 μM).

本文言語English
ページ(範囲)85-91
ページ数7
ジャーナルPhytochemistry Letters
31
DOI
出版ステータスPublished - 2019 6月
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生化学
  • 農業および作物学
  • 植物科学

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