TY - JOUR
T1 - Metabolic requirements for the maintenance of self-renewing stem cells
AU - Ito, Keisuke
AU - Suda, Toshio
N1 - Funding Information:
The authors thank C. Lin, A. Sasaki and A. Carracedo Pérez for their comments and discussion on metabolic pathways in stem cells. T.S. is supported by the Seventh Framework Programme of the European Union under grant agreement number 306240 (SystemAge) and a Grant-in-Aid from the Japan Society for the Promotion of Science. K.I. is supported by grants from the US National Institutes of Health (NIH) (R00CA139009 and R01DK98263). The authors apologize to those whose work could not be discussed owing to space limitations.
PY - 2014/4
Y1 - 2014/4
N2 - A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency. Studies of genetically-engineered mouse models and recent advances in metabolomic analysis, particularly in haematopoietic stem cells, have deepened our understanding of the contribution made by metabolic cues to the regulation of stem cell self-renewal. Many types of stem cells heavily rely on anaerobic glycolysis, and stem cell function is also regulated by bioenergetic signalling, the AKT-mTOR pathway, Gln metabolism and fatty acid metabolism. As maintenance of a stem cell pool requires a finely-tuned balance between self-renewal and differentiation, investigations into the molecular mechanisms and metabolic pathways underlying these decisions hold great therapeutic promise.
AB - A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency. Studies of genetically-engineered mouse models and recent advances in metabolomic analysis, particularly in haematopoietic stem cells, have deepened our understanding of the contribution made by metabolic cues to the regulation of stem cell self-renewal. Many types of stem cells heavily rely on anaerobic glycolysis, and stem cell function is also regulated by bioenergetic signalling, the AKT-mTOR pathway, Gln metabolism and fatty acid metabolism. As maintenance of a stem cell pool requires a finely-tuned balance between self-renewal and differentiation, investigations into the molecular mechanisms and metabolic pathways underlying these decisions hold great therapeutic promise.
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U2 - 10.1038/nrm3772
DO - 10.1038/nrm3772
M3 - Review article
C2 - 24651542
AN - SCOPUS:84896929687
SN - 1471-0072
VL - 15
SP - 243
EP - 256
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 4
ER -