TY - JOUR
T1 - Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy
T2 - a focus on cardiomyocytes
AU - Tanosaki, Sho
AU - Tohyama, Shugo
AU - Kishino, Yoshikazu
AU - Fujita, Jun
AU - Fukuda, Keiichi
N1 - Funding Information:
The present work was mainly supported by Projects for Technological Development, the Research Center Network for Realization of Regenerative Medicine by Japan, and the Japan Agency for Medical Research and Development (grant number: 20bm0404023h0003, to S. Tohyama).
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells. The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.
AB - Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells. The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.
KW - Cardiomyocytes
KW - Metabolism
KW - Pluripotent stem cells
KW - Regenerative therapy
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U2 - 10.1186/s41232-021-00156-9
DO - 10.1186/s41232-021-00156-9
M3 - Review article
AN - SCOPUS:85100265842
SN - 1880-9693
VL - 41
JO - Inflammation and Regeneration
JF - Inflammation and Regeneration
IS - 1
M1 - 5
ER -