Microbial glycoconjugates recognition with tlrs and nlrs in innate immunity

Yukari Fujimoto, Koichi Fukase

研究成果: Chapter

1 被引用数 (Scopus)


The innate immune system is fundamental to the recognition of microbial components with utilizing a series of the innate immune receptors, which triggers the activation of the entire immune system including the acquired immunity. The receptors recognize the molecular patterns of the compounds that are common and unique to the microbes. The microbial cell-surface components are the major ligands of the innate immune receptors such as Toll-like receptors (TLRs) and Nod-like receptors (NLRs). For example, the bacterial glycoconjugates lipopolysaccharide (LPS) and peptidoglycan (PGN) are recognized by TLR4 and Nod1/2, respectively. This chapter summarizes the major classes of the innate immune receptors with their ligands, particularly focusing on the structural features of the TLR4, Nod1, and Nod2 ligands with their immunostimulatory and immunomodulatory activities.

ホスト出版物のタイトルGlycoscience: Biology and Medicine
出版社Springer Japan
ISBN(印刷版)9784431548416, 9784431548409
出版ステータスPublished - 2015 1月 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般
  • 医学一般


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