Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Hideaki Kakeya; Naoko Sakai; Takeshi Sugai; Hiromichi Ohta

doi:10.1016/S0040-4039(00)79663-8

Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

Hideaki Kakeya, Naoko Sakai, Takeshi Sugai, Hiromichi Ohta

薬科学科

研究成果: Article › 査読

112 被引用数 (Scopus)

抄録

Many kinds of aromatic nitriles have been hydrolyzed to afford the corresponding amides and carboxylic acids, by the aid of enzyme system of Rhodococcus butanica. This enzymatic hydrolysis can be successfully applied to the kinetic resolution of α-arylpropionitriles, resulting in the formation of (R)-amides and (S)-carboxylic acids.

本文言語	English
ページ（範囲）	1343-1346
ページ数	4
ジャーナル	Tetrahedron Letters
巻	32
号	10
DOI	https://doi.org/10.1016/S0040-4039(00)79663-8
出版ステータス	Published - 1991 3月 4

ASJC Scopus subject areas

生化学
創薬
有機化学

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10.1016/S0040-4039(00)79663-8

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Microbial hydrolysis as a potent method for the preparation of optically active nitriles, amides and carboxylic acids

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