TY - JOUR
T1 - Microbiota in autoimmunity and tolerance
AU - Atarashi, Koji
AU - Honda, Kenya
N1 - Funding Information:
The work was supported by the Japan Science and Technology Agency for Precursory Research for Embryonic Science and Technology (PRESTO) and the Japan Society for the Promotion of Science NEXT program.
PY - 2011/12
Y1 - 2011/12
N2 - The composition of a host's intestinal microbiota directs the type of mucosal and systemic immune responses by affecting the proportion and number of functionally distinct T cell subsets. In particular, the microbiota composition affects the differentiation of intestinal Th17 cells and Foxp3 + regulatory T cells, both of which play critical roles in maintaining mucosal barrier functions and in controlling immunological homeostasis. In this review, we discuss the recent advances in our understanding of how the intestinal microbiota affects T cell differentiation and host susceptibility to autoimmune disease.
AB - The composition of a host's intestinal microbiota directs the type of mucosal and systemic immune responses by affecting the proportion and number of functionally distinct T cell subsets. In particular, the microbiota composition affects the differentiation of intestinal Th17 cells and Foxp3 + regulatory T cells, both of which play critical roles in maintaining mucosal barrier functions and in controlling immunological homeostasis. In this review, we discuss the recent advances in our understanding of how the intestinal microbiota affects T cell differentiation and host susceptibility to autoimmune disease.
UR - http://www.scopus.com/inward/record.url?scp=82955249159&partnerID=8YFLogxK
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U2 - 10.1016/j.coi.2011.11.002
DO - 10.1016/j.coi.2011.11.002
M3 - Review article
C2 - 22115876
AN - SCOPUS:82955249159
SN - 0952-7915
VL - 23
SP - 761
EP - 768
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -